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Endometrial intraepithelial neoplasia (EIN) is a premalignant lesion of the uterine lining that predisposes to endometrioid endometrial adenocarcinoma. It is composed of a collection of abnormal endometrial cells, arising from the glands that line the uterus , which have a tendency over time to progress to the most common form of uterine cancer ...
Pre-cancerous endometrial hyperplasias are also referred to as endometrial intraepithelial neoplasia. [41] Mutations in the KRAS gene can cause endometrial hyperplasia and therefore Type I endometrial cancer. [37] Endometrial hyperplasia typically occurs after the age of 40. [9]
High grade anal intraepithelial neoplasia. Progression of pancreatic intraepithelial neoplasia, including mutations. [1] Cervical intraepithelial neoplasia (CIN), spanning a bit more than 2/3 of the thickness of the cervical epithelium. Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an ...
Uterine adenomyoma, the localized form of uterine adenomyosis, is a tumor composed of endometrial gland tissue and smooth muscle in the myometrium. [2] Adenomyomas containing endometrial glands are also found outside of the uterus, most commonly on the uterine adnexa but can also develop at distant sites outside of the pelvis . [ 3 ]
Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus. Most cases of endometrial hyperplasia result from high levels of estrogens , combined with insufficient levels of the progesterone-like hormones which ordinarily counteract estrogen's proliferative effects on this ...
In the ovary, embryonal carcinoma is quite rare, amounting to approximately three percent of ovarian germ cell tumours. The median age at diagnosis is 15 years. Symptoms and signs are varied, and may include sexual precocity and abnormal (increased, reduced or absent) uterine bleeding.
Type 1 endometrial cancer is the most common endometrial cancer. [16] As many as 90% of patients diagnosed with Type 1 endometrial cancer are obese. [ 17 ] Although a correlation between obesity and ovarian cancer is possible, the association is predominantly found in low-grade subtypes of the cancer.
Sertoli–Leydig cell tumour is a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements.