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Urea in low doses is a humectant while at high doses (above 20%) it causes breakdown of protein in the skin. [ 9 ] Urea dissolves the intercellular matrix of the cells of the stratum corneum , promoting desquamation of scaly skin , eventually resulting in softening of hyperkeratotic areas. [ 5 ]
Epidermolytic hyperkeratosis (also known as "Bullous congenital ichthyosiform erythroderma," [7] "Bullous ichthyosiform erythroderma," [8]: 482 or "bullous congenital ichthyosiform erythroderma of Brocq" [9]) is a rare skin disease in the ichthyosis family, affecting around 1 in 250,000 people.
Calmurid Cream contained the active ingredients lactic acid and urea, [1] whereas Calmurid HC contained an additional ingredient, the mild corticosteroid hydrocortisone. Owing to lactic acid's keratolytic properties (to break down hard skin cells) and urea's hydrating properties, Calmurid was used primarily in the treatment of dry, scaly skin.
If you'd prefer to get injections, your provider will apply numbing cream before using a needle to transfer those polynucleotides directly into the dermis. And that's where things get tricky ...
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Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons , waxes , or polyethylene glycols as the vehicle for external skin application. [ 1 ]
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