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The hippocampus plays an important role in the transfer of information from short-term memory to long-term memory during encoding and retrieval stages. These stages do not need to occur successively, but are, as studies seem to indicate, and they are broadly divided in the neuronal mechanisms that they require or even in the hippocampal areas ...
Knockout studies in Aplysia sea slugs indicated that decreasing CREB function blocks long-term changes in synaptic function, but not short-term ones. [3] Changes in synaptic function (i.e., synaptic plasticity) are required for learning and memory [4] As evidence of this, a line of mice with a targeted disruption of the α and δ isoforms of CREB showed intact short-term memory, but disrupted ...
The hippocampus is also involved in memory consolidation, the slow process by which memories are converted from short to long term memory. This is supported by studies in which lesions are applied to rat hippocampi at different times after learning. [2] The process of consolidation may take up to a couple years.
Exercise improves working memory. A study of school children in Germany has shown that moderate exercise can improve working memory. This has the most benefit for those children who have demonstrated prior learning problems. [15] One neuroimaging study showed a relationship between fitness, hippocampal volume, and some types of memory tasks. [16]
The most common aspect of retrieval cues associated with reconstructive memory is the process that involves recollection. This process uses logical structures, partial memories, narratives, or clues to retrieve the desired memory. [29] However, the process of recollection is not always successful due to cue-dependent forgetting and priming.
Schaffer collaterals are the axons of the neurons in the CA3 regions of the hippocampus that form synapses in the CA1 regions. The hippocampus is a part of the feedback process that sends signals to stop cortisol production. Thus, a damaged hippocampus can cause memory loss and inability of cognitive function.
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Activation in the hippocampal region associated with episodic memory encoding has been shown to occur in the rostral portion of the region whereas activation associated with episodic memory retrieval occurs in the caudal portions. [20] This is referred to as the Hippocampal memory encoding and retrieval model or HIPER model.