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  2. Lidocaine - Wikipedia

    en.wikipedia.org/wiki/Lidocaine

    Impaired liver function – people with lowered hepatic function may have an adverse reaction with repeated administration of lidocaine because the drug is metabolized by the liver. Adverse reactions may include neurological symptoms (e.g. dizziness, nausea, muscle twitches, vomiting, or seizures).

  3. First pass effect - Wikipedia

    en.wikipedia.org/wiki/First_pass_effect

    The liver is the major site of first pass effect; however, it can also occur in the lungs, vasculature or other metabolically active tissues in the body. Notable drugs that experience a significant first pass effect are buprenorphine , chlorpromazine , cimetidine , diazepam , ethanol (drinking alcohol), imipramine , insulin , lidocaine ...

  4. Tumescent anesthesia - Wikipedia

    en.wikipedia.org/wiki/Tumescent_anesthesia

    The most common combination of agents used in tumescent anesthesia is lidocaine (0.05-0.10%) and epinephrine (1 ppm). [3] [4] [5] For lidocaine, total doses of 35 mg/kg [6] and 55 mg/kg [7] have been reported as reasonably safe high-end doses, in the context of liposuction.

  5. Local anesthetic - Wikipedia

    en.wikipedia.org/wiki/Local_anesthetic

    Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...

  6. Prilocaine - Wikipedia

    en.wikipedia.org/wiki/Prilocaine

    It is used as a eutectic mixture with lidocaine, 50% w/w, as lidocaine/prilocaine. The mixture is an oil with a melting point of 18 °C (64 °F). A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for eutectic mixture of local anesthetics). [3]

  7. Total intravenous anaesthesia - Wikipedia

    en.wikipedia.org/wiki/Total_intravenous_anaesthesia

    Pharmacodynamic and pharmacokinetic factors need to be considered for each patient (e.g. patients with impaired kidney or liver function, blood abnormalities and myocardial dysfunction, etc.) [16] There are also risks of adverse effects related to doses such as hypotension and respiratory depression. [17]

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  9. Liver support system - Wikipedia

    en.wikipedia.org/wiki/Liver_support_system

    A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).

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