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Mobile encapsulated fat necrosis (MEFN) is a rare medical condition featuring the formation of a fibrotic capsule around a small, necrotic mass of fatty tissue. It is asymptomatic and benign but may be mistaken for other neoplasms due to its typical presentation as a firm nodule beneath the skin that can be moved around within the tissue.
Recurrent ulceration and fat necrosis is associated with lipodermatosclerosis. In advanced lipodermatosclerosis the proximal leg swells from chronic venous obstruction and the lower leg shrinks from chronic ulceration and fat necrosis resulting in the inverted coke bottle appearance of the lower leg.
Lipoatrophy is the localised loss of fat in tissue. It is common in diabetics who use conventional insulin injection treatment. [4] In 1949, a much more pure form of insulin was, instead of causing lipoatrophy, shown to regenerate the localised loss of fat after injections in to diabetics. [4]
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Fat necrosis in the breast occurs around 0.6%, this represents 2.75% of lesions that end up being benign. However, 0.8% of fat necrosis occurs from tumors of the breast, 1–9% occurs in breast reduction surgery. Individuals that are high risk include women around the age of 50yrs along with pendulous breasts. [8]
Necrobiosis lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). [1] It can also occur in individuals with rheumatoid arthritis or without any underlying conditions (). [2]
In stage 4, deeper necrosis usually occurs, the fat underneath the skin is completely exposed, and the muscle may also become exposed. In the last two stages the sore may cause a deeper loss of fat and necrosis of the muscle; in severe cases it can extend down to bone level, destruction of the bone may begin, and there may be sepsis of joints .
Mueller–Weiss syndrome, also known as Mueller–Weiss disease, is a rare [2] idiopathic degenerative disease of the adult navicular bone characterized by progressive collapse and fragmentation, leading to mid- and hindfoot pain and deformity. [3] [1] It is most commonly seen in females, ages 40–60. [4]