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Polycythemia is defined as serum hematocrit (Hct) or hemoglobin (HgB) exceeding normal ranges expected for age and sex, typically Hct >49% in healthy adult men and >48% in women, or HgB >16.5 g/dL in men or >16.0 g/dL in women. [8] The definition is different for neonates and varies by age in children. [9] [10]
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Hematocrit levels that are too high or too low can indicate a blood disorder, dehydration, or other medical conditions. [4] An abnormally low hematocrit may suggest anemia , a decrease in the total amount of red blood cells, while an abnormally high hematocrit is called polycythemia . [ 5 ]
hemoconcentration (elevated hematocrit and hemoglobin readings, with hematocrit levels >49% in men and >43% in women, not because of an absolute increase in them but because of the leak of plasma); very low blood pressure (profound arterial hypotension, with systolic blood pressure levels <90 mm Hg);
The MCV can be conceptualized as the total volume of a group of cells divided by the number of cells. For a real world sized example, imagine you had 10 small jellybeans with a combined volume of 10 μL. The mean volume of a jellybean in this group would be 10 μL / 10 jellybeans = 1 μL / jellybean. A similar calculation works for MCV.
[15] [16] [17] Patients are usually designated as having a low or high risk of bleeding or developing blood clots based on their age, medical history, blood counts and their lifestyles. Low risk individuals are usually treated with aspirin , whereas those at high risk are treated with hydroxycarbamide , interferon-α or anagrelide ).
Basophilia is the condition of having greater than 200 basophils/μL in the venous blood. [1] Basophils are the least numerous of the myelogenous cells, and it is rare for their numbers to be abnormally high without changes to other blood components.
A high reticulocyte count signifies that bone marrow processes are normal. A low reticulocyte count would signify there is a problem at the level of the bone marrow, which produce the stem cells . Acute blood loss would result in a high reticulocyte count, as bone marrow processes are normal and the bone marrow responds accordingly to the body ...