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Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies (such as insect bites) and asthma. [1] [2] Immunotherapy involves exposing people to larger and larger amounts of allergens in an attempt to change the immune system's response.
Allergen immunotherapy is an alternative treatment considered in some patients, with a success rate of 80%-90% in reducing symptoms, [3] but requiring a much longer duration of therapy. The choice of medications depends on the disease to be treated, its severity and patient factors.
Desensitization approaches for food allergies are generally at the research stage. They include: [2] oral immunotherapy, which involves building up tolerance by eating a small amount of (usually baked) food; sublingual immunotherapy, which involves placing a small drop of milk or egg white under the tongue;
Curex is an American telehealth company specializing in immunology, specifically the diagnosis and treatment of allergies, including the prescription and delivery of allergy immunotherapy. [1] The company was founded by Gene Kakaulin and Charles Jacoby in 2020 [ 2 ] and is headquartered in New York City. [ 3 ]
Allergy immunotherapy can be administered orally (as sublingual tablets or sublingual drops), or by injections under the skin (subcutaneous). [46] [47] Immunotherapy contains a small amount of the substance that triggers the allergic reactions. [48] Ladders are also used for egg and milk allergies as a home-based therapy mainly for children.
In 1992, ALK and Abello merged. In the 1990s, ALK was the first company to launch sublingual immunotherapy drops (allergy immunotherapy administered as droplets under the tongue). In recent years, ALK's research and development strategy has been focused on introducing a range of sublingual immunotherapy tablets (SLIT-tablets).
In 2016: HAL Allergy has successfully completed the First-In-Human study with their subcutaneous immunotherapeutic drug for peanut allergy. [6] In 2016: HAL Allergy has successfully completed its Phase III short-term efficacy trial with its sublingual allergen immunotherapy (SLIT) liquid product for the treatment of birch pollen allergy. [7]
Allergen immunotherapy is the only treatment that alters the disease mechanism. [27] Immunotherapy can be administered orally (as sublingual tablets [28] or sublingual drops), or by injections under the skin (subcutaneous). [29] Subcutaneous immunotherapy is the most common form and has the largest body of evidence supporting its effectiveness ...