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Some researchers are investigating how metformin, a common drug used to treat diabetes, may help prolong healthspan and lifespan. What evidence is there to support this notion?
Hemoglobin-AGE levels are elevated in diabetic individuals [24] and other AGE proteins have been shown in experimental models to accumulate with time, increasing from 5-50 fold over periods of 5–20 weeks in the retina, lens and renal cortex of diabetic rats. The inhibition of AGE formation reduced the extent of nephropathy in diabetic rats. [25]
Gastrointestinal upset can cause severe discomfort; it is most common when metformin is first administered, or when the dose is increased. [75] [80] The discomfort can often be avoided by beginning at a low dose (1.0 to 1.7 g/day) and increasing the dose gradually, but even with low doses, 5% of people may be unable to tolerate metformin.
Metformin can also cause a vitamin B12 deficiency, which may be linked with anemia. Stopping the medication or starting vitamin B12 supplementation appears to reverse this. Seek medical advice if ...
The official use of metformin is to lower blood sugar for people with type 2 diabetes. Metformin does this by improving the body’s ... incidence of age-related diseases like cardiovascular ...
The eyes can also be affected in other ways, including development of cataract and glaucoma. [22] It is recommended that people with diabetes visit an optometrist or ophthalmologist once a year. [31] Diabetic nephropathy is a major cause of chronic kidney disease, accounting for over 50% of patients on dialysis in the United States. [32]
So, does metformin cause hair loss? We have answers. ... 75 percent of men who used a non-therapeutic placebo experienced worsening hair loss over the same period. ... Most guys shed 50 and 100 ...
Many people, however, have no symptoms during the first few years and are diagnosed on routine testing. [13] A small number of people with type 2 diabetes can develop a hyperosmolar hyperglycemic state (a condition of very high blood sugar associated with a decreased level of consciousness and low blood pressure). [13]