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  2. Promethazine - Wikipedia

    en.wikipedia.org/wiki/Promethazine

    Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold [ 4 ] and may also be used for sedating people who are agitated or anxious, an effect that has led to ...

  3. List of cytochrome P450 modulators - Wikipedia

    en.wikipedia.org/wiki/List_of_cytochrome_P450...

    See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including: CYP7A1 (cholesterol 7α-hydroxylase) CYP7B1 (25-hydroxycholesterol 7α-hydroxylase) CYP8B1 (sterol 12α-hydroxylase) CYP11A1 (cholesterol side-chain cleavage enzyme; P450scc) CYP11B1 (steroid 11β-hydroxylase) CYP11B2 (aldosterone synthase)

  4. CYP2D6 - Wikipedia

    en.wikipedia.org/wiki/CYP2D6

    The gene is located on chromosome 22q13.1. near two cytochrome P450 pseudogenes (CYP2D7P and CYP2D8P). [16] Among them, CYP2D7P originated from CYP2D6 in a stem lineage of great apes and humans, [17] the CYP2D8P originated from CYP2D6 in a stem lineage of Catarrhine and New World monkeys' stem lineage. [18]

  5. List of polysubstance combinations - Wikipedia

    en.wikipedia.org/wiki/List_of_polysubstance...

    Ethanol is metabolized into cocaethylene: Cocaine: Quetiapine: Q-ball Codeine: Glutethimide: Pancakes and syrups Combination of glutethimide and codeine cough syrup Codeine: Promethazine: Lean, purple drank, oil Crack cocaine: Fentanyl: Dirty fentanyl, takeover [citation needed] Crack cocaine: Heroin: Chocolate rock, dragon rock, eightball ...

  6. Hydroxyzine - Wikipedia

    en.wikipedia.org/wiki/Hydroxyzine

    Hydroxyzine is rapidly absorbed and distributed with oral and intramuscular administration, and is metabolized in the liver; the main metabolite (45%), cetirizine, is formed through oxidation of the alcohol moiety to a carboxylic acid by alcohol dehydrogenase, and overall effects are observed within one hour of administration. Higher ...

  7. Chlorpromazine - Wikipedia

    en.wikipedia.org/wiki/Chlorpromazine

    The major routes of metabolism include hydroxylation, N-oxidation, sulfoxidation, demethylation, deamination and conjugation. There is little evidence supporting the development of metabolic tolerance or an increase in the metabolism of chlorpromazine due to microsomal liver enzymes following multiple doses of the drug.

  8. Isopromethazine - Wikipedia

    en.wikipedia.org/wiki/Isopromethazine

    This pharmacology -related article is a stub. You can help Wikipedia by expanding it.

  9. Glucuronidation - Wikipedia

    en.wikipedia.org/wiki/Glucuronidation

    Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds. [1]

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