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The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a physician and practicing histologist at the Mayo Clinic. [5] Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with ...
In diagnostic pathology, a hematoxylin body, or LE body, is a dense, homogeneous, basophilic particle, easily stainable with hematoxylin. It consists of degraded nuclear material from an injured cell, along with autoantibodies and a limited amount of cytoplasm. [1] [2] [3] Hematoxylin bodies occur in systemic lupus erythematosus.
The lupus erythematosus (LE) cell test was commonly used for diagnosis, but it is no longer used because the LE cells are only found in 50–75% of SLE cases and they are also found in some people with rheumatoid arthritis, scleroderma, and drug sensitivities. Because of this, the LE cell test is now performed only rarely and is mostly of ...
HEp-2 cells provide a greater ability to differentiate patterns of ANA than animal sections, due to the large nuclei and high mitotic rate of the cell line. Upon incubation with serum containing anti-dsDNA antibodies and fluorescent labelled secondary antibodies, homogeneous staining of interphase nuclei and condensed chromosomal staining of ...
Rheumatology, immunology Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues . [ 1 ] Symptoms of these diseases can affect many different body systems, including joints , skin , kidneys , blood cells , heart , and lungs .
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LE cell. The LE cell was discovered in bone marrow in 1948 by Hargraves et al. [70] In 1957 Holborow et al. first demonstrated ANA using indirect immunofluorescence. [71] This was the first indication that processes affecting the cell nucleus were responsible for SLE.
South. Ham – especially country ham – is a more common Christmas main dish in the South than elsewhere in the country, along with sides including mac & cheese and cornbread.Lechon, or spit ...