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  2. Cushing's disease - Wikipedia

    en.wikipedia.org/wiki/Cushing's_disease

    Any intermediate values need to be cautiously interpreted and a corticotropin-releasing hormone (CRH) test is advised in order to confirm corticotropin dependency. If corticotropin-dependent Cushing's syndrome is determined then the next step is to distinguish between Cushing's disease and ectopic corticotropin syndrome.

  3. Dexamethasone suppression test - Wikipedia

    en.wikipedia.org/wiki/Dexamethasone_suppression_test

    Results indicative of Cushing's disease involve no change in cortisol on low-dose dexamethasone, but inhibition of cortisol on high-dose dexamethasone. If the cortisol levels are unchanged by low- and high-dose dexamethasone, then other causes of Cushing's syndrome must be considered with further work-up necessary.

  4. Cushing's syndrome - Wikipedia

    en.wikipedia.org/wiki/Cushing's_syndrome

    Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...

  5. 12 Signs of Cushing Syndrome and What to Do if You ... - AOL

    www.aol.com/12-signs-cushing-syndrome-think...

    Cushing syndrome symptoms. Not everyone has the same symptoms with Cushing syndrome, but the Cleveland Clinic says they may include: Rapid weight gain in the face, abdomen, back of the neck, and chest

  6. Primary pigmented nodular adrenocortical disease - Wikipedia

    en.wikipedia.org/wiki/Primary_pigmented_nodular...

    PPNAD, the endocrine manifestation that comes from Carney Complex (CNC), can be syndromic or isolated. The main cause of isolated PPNAD is a mutation of PRKAR1α, located at 17q22-24, which is the gene encoding the regulatory R1α subunit of protein kinase A. Germline heterozygous PRKAR1α inactivation mutations are present in 80% of CNC patients affected by Cushing's syndrome. [8]

  7. Pseudo-Cushing's syndrome - Wikipedia

    en.wikipedia.org/wiki/Pseudo-Cushing's_syndrome

    Pseudo-Cushing's syndrome or non-neoplastic hypercortisolism is a medical condition in which patients display the signs, symptoms, and abnormal cortisol levels seen in Cushing's syndrome. However, pseudo-Cushing's syndrome is not caused by a problem with the hypothalamic-pituitary-adrenal axis as Cushing's is; it is mainly an idiopathic ...

  8. Inferior petrosal sinus sampling - Wikipedia

    en.wikipedia.org/wiki/Inferior_petrosal_sinus...

    Inferior petrosal sinus sampling (or IPSS), is a diagnostic medical procedure used to determine whether excess adrenocorticotropic hormone (ACTH) is coming from the pituitary gland (usually a pituitary adenoma causing Cushing's disease) or from a source outside the pituitary (a rare tumor causing ectopic ACTH syndrome). The procedure is usually ...

  9. Adrenocortical adenoma - Wikipedia

    en.wikipedia.org/wiki/Adrenocortical_adenoma

    The term "Cushing's disease" refers specifically to "secondary hypercortisolism" classified as "ACTH-dependent Cushing's syndrome" caused by pituitary adenomas. In contrast, "Cushing's syndrome" refers specifically to "primary hypercortisolism" classified as "ACTH-independent Cushing's syndrome" caused by adrenocortical adenomas.

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