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Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. [4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. [ 10 ] [ 11 ] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder . [ 5 ]
The dose range advised by the manufacturers is 20–40 μg/kg intravenous for moderate sedation, but this dose may need to be higher if given intramuscularly. When given intravenously, detomidine usually takes effect in 2–5 minutes, and recovery is full within 30–60 minutes.
Minimum alveolar concentration or MAC is the concentration, often expressed as a percentage by volume, of a vapour in the alveoli of the lungs that is needed to prevent movement (motor response) in 50% of subjects in response to surgical (pain) stimulus.
Arkansas said it ran out of ICU beds for COVID-19 patients for the first time since the pandemic began. Nearly 80% of the country's ICU beds — or about 68,000 — were in use Thursday, according ...
In the European Union, dexmedetomidine received a marketing authorization from the European Medicines Agency (EMA) on August 10, 2012, under the brand name of Dexdor. [27] It is indicated for sedation in the ICU for patients needing mechanical ventilation.
Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
model to assess risk of death at ICU admission; has prediction models for assessment at admittance, 24h, 48h and 72h after; RIFLE - Risk, injury, failure, loss and end-stage kidney classification [2] has 3 severity levels (risk, injury and failure) and 2 possible outcomes (loss and end-stage) CP - Child–Pugh score [2] for patient with liver ...
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