Search results
Results from the WOW.Com Content Network
Fenamic acid is a derivative of anthranilic acid, [18]: 235 which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin. [ 18 ] : 235 Several non-steroidal anti-inflammatory drugs , including mefenamic acid , tolfenamic acid , flufenamic acid , and meclofenamic acid are derived from fenamic acid or ...
These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid. [2]: 235 [3]: 17 [2] Fenamic acid can be synthesized from 2-chlorobenzoic acid and can be converted into acridone. [4]
Anthranilic acid derivatives (Fenamates) [ edit ] The following NSAIDs are derived from fenamic acid , which is a derivative of anthranilic acid , [ 143 ] : 235 which in turn is a nitrogen isostere of salicylic acid , which is the active metabolite of aspirin .
Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs), and is used to treat mild to moderate pain. [4] [5] Its name derives from its systematic name, dimethylphenylaminobenzoic acid. It was discovered and brought to market by Parke-Davis as Ponstel in the 1960s.
Flufenamic acid (FFA) is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs). [1]: 718 Like other members of the class, it is a cyclooxygenase (COX) inhibitor, preventing the formation of prostaglandins. [2]
Tolfenamic acid, belonging to the pharmacological group of fenamates, possesses a chemical structure typical of anthranilic acid derivatives. In this structure, one of the hydrogen atoms of the nitro group is substituted by a benzene ring featuring a methyl group and a chlorine atom at the ortho- and meta- positions, respectively.
Folpet, a phthalimide, is a commercial fungicide. [3]Phthalimide is used as a precursor to anthranilic acid, a precursor to azo dyes and saccharin. [2]Alkyl phthalimides are useful precursors to amines in chemical synthesis, especially in peptide synthesis where they are used "to block both hydrogens and avoid racemization of the substrates". [4]
Meclofenamic acid (used as meclofenamate sodium, brand name Meclomen) is a drug used for joint, muscular pain, arthritis and dysmenorrhea. [1] It is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs) and was approved by the US FDA in 1980. [ 2 ]