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Dronabinol is the principal psychoactive constituent enantiomer form, (−)-trans-Δ 9-tetrahydrocannabinol, found in Cannabis sativa L. plants, [8] but can also be synthesized in laboratory. Dronabinol does not include any other tetrahydrocannabinol (THC) isomers or any cannabidiol.
THC was reported to have a fast initial half-life of 6 minutes and a long terminal half-life of 22 hours in a population pharmacokinetic study. [23] [33] Conversely, the Food and Drug Administration label for dronabinol reports an initial half-life of 4 hours and a terminal half-life of 25 to 36 hours. [22]
Cannabinoids, including tetrahydrocannabinol (THC), the active drug in cannabis, can also be produced by bioengineered yeast, a process colloquially known as pharming. [1] In 2007, a research group reported the successful transgenic placement of a THCA synthase gene from Cannabis plant into the Pichia pastoris yeast, giving the yeast the ability to turn the precursor molecule cannabigerolic ...
Most people 50 and older who use cannabis do so at least once a month, saying it helps them sleep and eases pain, a new survey found. More than 20% of older adults have used pot in the past year ...
[9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9] Beginning with the formation of 3,5,7-trioxododecaneoyl-COA by the condensation reaction between hexanoyl-CoA and malonyl-CoA , catalyzed by type III polyketide synthase (PKS), the product is then used to form ...
Sleep plays a vital role in regulating metabolism and appetite. When sleep deprived, the metabolic system will be out of balance, which will ultimately affect the dietary choices people make. Teens who are sleep deprived crave more carbohydrates. Sleep deprivation is a risk factor for obesity among young adults. [7] [medical citation needed]
“Here, we also do not know what happens when mice are sleep-deprived for a longer time period, say chronically, when they are under a greater homeostatic sleep pressure and under stress from ...
Cannabis material can be leached in high-proof spirits (often grain alcohol) to create a "Green Dragon". Cannabis can also be consumed as a cannabis tea and many other beverages. Although THC is lipophilic and only slightly water soluble (with a solubility of 2.8 mg per liter), [13] enough THC can be dissolved to make a mildly psychoactive tea ...
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