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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Free radicals can oxidize LDL, and this is a key event in the formation of plaque in arteries, leading to heart disease and stroke. [23] These are examples of how the free-radical theory of aging has been used to neatly "explain" the origin of many chronic diseases. [24]
Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10 and 15 per thousand person-years for all dementias and 5–8 for AD, [236] [237] which means that half of new dementia cases each year are Alzheimer's disease. Advancing age is a primary risk factor for ...
The treatment will depend on the cause of memory loss, but various drugs to treat Alzheimer's disease have been suggested in recent years. There are four drugs currently approved by the Food and Drug Administration (FDA) for the treatment of Alzheimer's, and they all act on the cholinergic system: Donepezil , Galantamine , Rivastigmine , and ...
Yan Hui, a student of Confucius, aged rapidly and died at a young age, appearing as an old man by his late 20s. He may be one of the earliest potential examples of progeria in history. [84] [failed verification] In 1987, fifteen-year-old Mickey Hays, who had progeria, appeared along with Jack Elam in the documentary I Am Not a Freak. [85]
Pathology is the medical discipline that describes conditions typically observed during a disease state, whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism. Pathology describes the abnormal or undesired condition (symptoms of a disease), whereas pathophysiology seeks to explain ...
The five-year survival rate is about 35% in people under 60 years old and 10% in people over 60 years old. [3] Older people whose health is too poor for intensive chemotherapy have a typical survival of five to ten months. [3] It accounts for roughly 1.1% of all cancer cases, and 1.9% of cancer deaths in the United States. [2]