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English: Stop the Spread of Germs: Help prevent the spread of respiratory diseases, like coronavirus disease 2019 by avoiding close contact with people who are sick; covering cough and sneeze; avoiding touching eyes, nose and mouth; and washing your hands with soap and water.
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This process uses a non-germ-free mother which is sacrificed and sterilized before the pups' birth. After the cesarean birth, the pups must then be transferred to a sterile incubator with a germ-free mother for feeding and growth. [9] [10] These methods are only required for the generation of a germ-free mouse line. Once a line is generated ...
These PGCs will later give rise to germline sperm cells or egg cells. At this point the PGCs have high typical levels of methylation. Then primordial germ cells of the mouse undergo genome-wide DNA demethylation, followed by subsequent new methylation to reset the epigenome in order to form an egg or sperm. [25]
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