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Retinol binding protein 4, also known as RBP4, is a transporter protein [5] for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans.
Retinol plays a crucial role in the growth and differentiation of various body tissues, and it has been previously characterized that embryos are extremely sensitive to alterations in retinol concentration that can lead to spontaneous abortion and malformations occurring during development.
5928 19646 Ensembl ENSG00000162521 ENSMUSG00000057236 UniProt Q09028 Q60972 RefSeq (mRNA) NM_005610 NM_001135255 NM_001135256 NM_009030 RefSeq (protein) NP_001128727 NP_001128728 NP_005601 NP_033056 Location (UCSC) Chr 1: 32.65 – 32.69 Mb Chr 4: 129.2 – 129.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a ...
Retinoic acid is actively transported into the cell nucleus by CRABp2 where it regulates thousands of genes by binding directly to gene targets via retinoic acid receptors. [6] In addition to retinol, retinal and retinoic acid, there are plant-, fungi- or bacteria-sourced carotenoids which can be metabolized to retinol, and are thus vitamin A ...
Fetuin-A was the first hepatokine to be described and correlated with increased inflammation and insulin resistance. [5]Fetuin-B significantly increases hepatic steatosis and mediates impaired insulin action and glucose intolerance.
RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision.
RBP4 has recently been linked to autosomal dominant form of anophthalmia. [4] This form of anophthalmia has variable penetrance and a unique maternal inheritance effect that is rooted in pregnancy. Specifically, the disease only occurs when a mother and fetus both carry a RBP4 mutation which predisposes the fetus to vitamin A deficiency (a ...
5433 69241 Ensembl ENSG00000144231 ENSMUSG00000024258 UniProt O15514 Q9D7M8 RefSeq (mRNA) NM_004805 NM_027002 NM_001357480 RefSeq (protein) NP_004796 NP_081278 NP_001344409 Location (UCSC) Chr 2: 127.84 – 127.86 Mb Chr 18: 31.92 – 31.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D ...