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Clofazimine also showed a dosage-dependent inhibition of neutrophil motility, lymphocyte transformation, [19] mitogen-induced PBMC proliferation [20] and complement-mediated solubilization of pre-formed immune complexes in vitro. [21] A mechanistic studying of clofazimine in human T cells revealed that this drug is a Kv1.3 channel blocker. [22]
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions).
This is a major advantage of clofazimine over other antileprosy drugs. Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. The most disturbing adverse reaction to clofazimine is a red-brown ...
They first synthesised B663 in 1954, and it was launched as the anti-leprosy drug clofazimine in 1957. [6] [7] [8] From the middle of the 1960s, Barry's research moved towards investigating the chemotherapy of cancer. Barry travelled the world lecturing and with his research team published over 170 papers. [1]
The term "induction regimen" refers to a chemotherapy regimen used for the initial treatment of a disease. A "maintenance regimen" refers to the ongoing use of chemotherapy to reduce the chances of a cancer recurring or to prevent an existing cancer from continuing to grow. [2]
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]
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