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Clofazimine is a phenazine dye and is believed to work by interfering with DNA. [1] Clofazimine was discovered in the 1950s at Trinity College, Dublin, [6] and approved for medical use in the United States in 1986. [1] It is on the World Health Organization's List of Essential Medicines. [7]
Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned persons.
Clinical Practice Guidelines We Can Trust. Washington, DC: National Academies Press. doi:10.17226/13058. ISBN 978-0-309-16422-1. PMID 24983061. Marcum, Zachary A.; Hanlon, Joseph T. (April 2012). "Commentary on the New American Geriatric Society Beers Criteria for Potentially Inappropriate Medication Use in Older Adults".
Geriatrics, or geriatric medicine, [1] is a medical specialty focused on providing care for the unique health needs of the elderly. [2] The term geriatrics originates from the Greek γέρων geron meaning "old man", and ιατρός iatros meaning "healer".
A clinical trial studying the use of thalidomide in leprosy soon followed. [ 58 ] Thalidomide has been used by Brazilian physicians as the drug of choice for the treatment of severe ENL since 1965, and by 1996, at least 33 cases of thalidomide embryopathy were recorded in people born in Brazil after 1965. [ 59 ]
The term "steroid dementia" was coined by Varney et al. (1984) in reference to the effects of long-term glucocorticoid use in 1,500 patients. [3] While the condition generally falls under the classification of Cushing's syndrome , the term "steroid dementia syndrome" is particularly useful because it recognizes both the cause of the syndrome ...
An old man at a nursing home in Norway. Elderly care, or simply eldercare (also known in parts of the English-speaking world as aged care), serves the needs of old adults.It encompasses assisted living, adult daycare, long-term care, nursing homes (often called residential care), hospice care, and home care.
On October 16, 2007, it was given the status of Orphan drug by the U.S. Food and Drug Administration (FDA) for use against drug-susceptible and drug-resistant TB bacteria. [ 3 ] SQ109 completed three phase I studies in the U.S. and one Phase II efficacy studies in tuberculosis patients in Africa.