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The symptoms of rhabdomyolysis depend on its severity and whether kidney failure develops. Milder forms may not cause any muscle symptoms, and the diagnosis is based on abnormal blood tests in the context of other problems.
Elevated levels of serum CK greater than 5,000 U/L that are not caused by myocardial infarction, brain injury or disease, generally indicate serious muscle damage confirming the diagnosis of ER. [17] Urine is often a dark "cola" color as a result of the excretion of muscle cell components.
[2] [3] [4] He studied the pathology of three soldiers who died in World War I due to kidney failure. The renal changes were due to the buildup of excess myoglobin, resulting from the destruction of muscles from lack of oxygen. The progressive acute kidney failure is because of acute tubular necrosis.
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Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease. [5] [6] Risk factors include a family history of chronic kidney disease. [2] Diagnosis is by blood tests to measure the estimated glomerular filtration rate (eGFR), and a urine test to measure albumin. [8]
Wen: Diagnosis is made through a combination of the person’s medical history, physical exam and diagnostic tests. The tests could include a chest X-ray or CT scan. The tests could include a ...
The key factor in acute compartment syndrome is the time to diagnosis and fasciotomy. [12] A missed or late diagnosis may require limb amputation to survive. [63] [13] After a fasciotomy, some symptoms may be permanent. [13] It depends on which compartment was affected, the time until surgery, and muscle necrosis.
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys' filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include: McArdle's disease