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Reproductive factors like starting your period later, entering menopause earlier, and using oral contraceptives or hormone replacement therapy have also been found to increase gout risk.
Gout presenting as slight redness in the metatarsophalangeal joint of the big toe. Gout can present in several ways, although the most common is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint). [4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases ...
Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and pain, using a low-dose prescription of 0.6 to 1.2 mg per day, or a high-dose amount of up to 4.8 mg in the first 6 hours of a gout episode. [14] [26] With an oral dose of 0.6 mg, peak blood levels occur within one to two hours. [50]
Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. [ 2 ]
After menopause the vaginal epithelium changes and becomes a few layers thick. [18] Many of the signs and symptoms that accompany menopause occur in atrophic vaginitis. [3] The earliest symptoms of atrophic vaginitis may be decreased vaginal lubrication, while other symptoms may appear later. [14] Genitourinary symptoms include dryness [3] [19 ...
Hymenorrhaphy or "hymen reconstruction surgery" is the surgical alteration of the hymen, with the goal of producing bleeding on intercourse and a tight vaginal introitus, falsely believed to indicate virginity. The term comes from the Greek words hymen meaning "membrane", and raphḗ meaning "suture".
Bone resorption rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause. [7] Common treatments include drugs that increase bone mineral density. Bisphosphonates , RANKL inhibitors , SERMs— selective oestrogen receptor modulators , hormone replacement therapy and calcitonin are some of the common ...
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