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Glycerol kinase deficiency has two main causes.. The first cause is isolated enzyme deficiency. The enzyme glycerol kinase is encoded by the X-chromosome in humans. [8] It acts as a catalyst in the phosphorylation of glycerol to glycerol-3-phosphate which plays a key role in formation of triacylglycerol (TAG) and fat storage.
Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.. Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate:
The G protein-coupled inwardly rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs).
SK potassium channels share the same basic architecture with Shaker-like voltage-gated potassium channels. [9] Four subunits associate to form a tetramer.Each of the subunits has six transmembrane hydrophobic alpha helical domains (S1-S6).
Glucokinase can be rapidly activated and inactivated in hepatocytes by a novel regulatory protein (glucokinase regulatory protein), which operates to maintain an inactive reserve of GK, which can be made quickly available in response to rising levels of portal vein glucose.
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location [1] [2] of this key enzyme of glucose metabolism.
Compared to western European countries, there is an intrinsic "tradition" of teachers granting students rather more marks at the "good" end of the scale, i.e. more 1s, 2s and 3s than they would receive in western Europe, for example. Students below the university level receive school reports (lists of final marks) at the end of each semester.
Let G be a real Lie group. Let be its Lie algebra, and K a maximal compact subgroup with Lie algebra .A (,)-module is defined as follows: [3] it is a vector space V that is both a Lie algebra representation of and a group representation of K (without regard to the topology of K) satisfying the following three conditions
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