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In 1911, the anaesthetist Arthur Ernest Guedel first described the use of self-administration of a nitrous oxide and oxygen mix. It was not until 1961 that the first paper was published by Michael Tunstall and others, describing the administration of a pre-mixed 50:50 nitrous oxide and oxygen mix, which led to the commercialisation of the product.
The use of nitrous oxide as a recreational drug at "laughing gas parties", primarily arranged for the British upper class, became an immediate success beginning in 1799. While the effects of the gas generally make the user appear stuporous, dreamy and sedated, some people also "get the giggles" in a state of euphoria, and frequently erupt in ...
Nitrous oxide (N 2 O), commonly referred to as laughing gas, along with various street names, is an inert gas which can induce euphoria, dissociation, hallucinogenic states of mind, and relaxation when inhaled. [1] Nitrous oxide has no acute biochemical or cellular toxicity and is not metabolized in humans or other mammals.
Joseph Priestley (1733–1804) was an English polymath who discovered nitrous oxide, nitric oxide, ammonia, hydrogen chloride, and (along with Carl Wilhelm Scheele and Antoine Lavoisier) oxygen. Beginning in 1775, Priestley published his research in Experiments and Observations on Different Kinds of Air , a six-volume work. [ 78 ]
Gardner Quincy Colton. Gardner Quincy Colton (February 7, 1814, Georgia, Vermont – August 10, 1898, Geneva, Switzerland) was an American showman, medicine man, lecturer, and former medical student who pioneered the use of nitrous oxide, or laughing gas, in dentistry.
Nitrous oxide is thought to be particularly non-toxic, though heavy long-term use can lead to a variety of serious health problems linked to the destruction of vitamin B12 and folic acid. [17] [18] Nitrous oxide "whippets" are small aerosol containers designed for charging whipped cream dispensers.
For example, in the UK the limits are typically 100ppm for nitrous oxide and 50ppm for halogenated volatile anaesthetic agents (except halothane which is 10ppm). Other jurisdictions have different requirements for local environmental contamination, for example, nitrous oxide maximum 25ppm and halogenated volatile gases maximum 2ppm.
In medicine, exhaled nitric oxide (eNO - now commonly known as FeNO) can be measured in a breath test for asthma and other respiratory conditions characterized by airway inflammation. Nitric oxide (NO) is a gaseous molecule produced by certain cell types in an inflammatory response.