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The test can detect antipsychotic-like activity both in the case of dopamine D 2 receptor antagonists and in the case of drugs lacking D 2 receptor antagonism. [1] [2] [6] The occupancy of the D 2 receptor by antagonists of this receptor required to inhibit the CAR is around 65 to 80%, which is similar to the occupancy at which therapeutic antipsychotic effects occur in humans with these drugs.
The European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes, sometimes simply referred to as the animal experimentation convention or laboratory animals convention, [1] is an animal welfare treaty of the Council of Europe regarding animal testing, adopted on 18 March 1986 in Strasbourg, and effective since 1 January 1991.
Prior to testing, the animals are usually given the opportunity to explore the environments to habituate and reduce the effects of novelty. Preference tests can be used to test for preferences of only one characteristic of an environment, e.g. cage colour, or multiple characteristics e.g. a choice between hamster wheel , Habitrail tunnels or ...
Download as PDF; Printable version; In other projects ... The UFAW Handbook is a manual about care of animals used in animal testing. It is presented by the ...
Directive 2010/63/EU is the European Union legislation that protects animals being used in research. Directive 2010/63/EU [1] is the European Union (EU) legislation "on the protection of animals used for scientific purposes" and is one of the most stringent ethical and welfare standards worldwide.
Killylea (/ k ɪ l iː ˈ l eɪ /; from Irish Coillidh Léith 'grey forest') is a small village and townland in Northern Ireland. It is within the Armagh City and District Council area. The village is set on a hill, with St Mark's Church of Ireland , built in 1832, at its summit.
Faunalytics is a nonprofit organization that provides animal advocates with access to the research and analysis of various animal issues. [1] [2] [3] Its research areas include factory farming, veganism and vegetarianism, companion animals, animal testing, hunting, animal trapping, wild animal suffering, and the use of animals for entertainment purposes (zoos, circuses, racing, fights, etc.). [4]
The light-dark box test (LDB) is a popular animal model used in pharmacology to assay unconditioned anxiety responses in rodents. [1] The extent to which behavior in the LDB measures anxiety is controversial.