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On November 21, 2004, 60 Minutes aired a report on the effectiveness of the plant as a natural appetite suppressant. [14] The media coverage and heavy marketing by nutritional supplement companies have created such a demand for Hoodia spp. plants that a protected status was imposed in several countries, such as Namibia.
In 2006, the plant became internationally known, after a marketing campaign falsely claimed that its use as a dietary supplement was an appetite suppressant for weight loss. [7] As of 2018, there is no high-quality clinical research showing that hoodia has actions as an appetite suppressant or is effective for weight loss. [8]
P57 is an oxypregnane steroidal glycoside isolated from the African cactiform Hoodia gordonii. P57 is hypothesized to be the chemical constituent from this plant mainly responsible for the putative appetite suppressant activity of Hoodia extracts. [1] [2] [3]
What is an appetite suppressant? On a basic level, an appetite suppressant is anything that impacts your desire to eat, says dietitian Scott Keatley, RD, co-owner of Keatley Medical Nutrition Therapy.
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Hoodia gordonii, used by the San, was patented by the South African Council for Scientific and Industrial Research (CSIR) in 1998, for its presumed appetite suppressing quality, although, according to a 2006 review, no published scientific evidence supported hoodia as an appetite suppressant in humans. [73]
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Phenmetrazine has been used as an appetite suppressant for purposes of weight loss. [2] It was used therapeutically for this indication at a dosage of 25 mg two or three times per day (or 50–75 mg/day total) in adults. [2] Phenmetrazine has been found to produce similar weight loss to dextroamphetamine in people with obesity. [3]
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