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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
The mechanism of action of biguanides is not fully understood, and many mechanisms have been proposed for metformin. [citation needed]Biguanides do not affect the output of insulin, unlike other hypoglycemic agents such as sulfonylureas and meglitinides.
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It acts as a serotonin 5-HT 2A receptor agonist, serotonin 5-HT 2B receptor antagonist, and also interacts with other serotonin receptors, such as the serotonin 5-HT 1F receptor (agonist), 5-HT 2C receptor (very weak partial agonist or antagonist), and 5-HT 6 receptor (agonist).
Ministry of Research and Technology of the Republic of Indonesia (abbreviated as Kemenristek, or RISTEK-BRIN on its logo) was a government ministry that has the task of conducting affairs in the field of research, science and technology to assist the President of Indonesia in carrying out state. The ministry was formerly known as the Ministry ...
The Indonesian Food and Drug Authority (Indonesian: Badan Pengawas Obat dan Makanan, lit. 'Food and Drug Supervisory Agency'), Badan POM/BPOM, or Indonesian FDA is a government agency of Indonesia responsible for protecting public health through the control and supervision of prescription and over-the-counter pharmaceutical drugs (medication), vaccines, biopharmaceuticals, dietary supplements ...
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