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The G-quadruplex decoy strategy is another promising approach for targeting cancer cells by exploiting the unique structural features of the G-quadruplex. The strategy involves designing synthetic oligonucleotides that mimic the G-quadruplex structure and compete with the endogenous G-quadruplexes for binding to transcription factors.
The objective of cancer screening is to detect cancer before symptoms appear, involving various methods such as blood tests, urine tests, DNA tests, and medical imaging. [ 1 ] [ 2 ] The purpose of screening is early cancer detection, to make the cancer easier to treat and extending life expectancy. [ 3 ]
Because of inherent limits in the DNA repair mechanisms, if humans lived long enough, they would all eventually develop cancer. [87] [88] DNA damages that are naturally occurring, due to normal cellular processes that produce reactive oxygen species, the hydrolytic activities of cellular water, etc., also occur frequently. Although most of ...
An influential task force just updated guidance on breast cancer screenings for at-risk women. They recommended every-other-year mammograms starting at age 40, a decade earlier than previous guidance.
A genetic screen or mutagenesis screen is an experimental technique used to identify and select individuals who possess a phenotype of interest in a mutagenized population. [1] Hence a genetic screen is a type of phenotypic screen.
Cervical cancer screening is a medical screening test designed to identify risk of cervical cancer. Cervical screening may involve looking for viral DNA, and/or to identify abnormal, potentially precancerous cells within the cervix as well as cells that have progressed to early stages of cervical cancer .
The amount of fetal DNA is assessed to determine if there is extra fetal genetic material present that may indicate an increased risk that the fetus has Down Syndrome or other selected conditions. As this is a screening test, other diagnostic tests such as amniocentesis or chorionic villus sampling are needed to confirm a diagnosis.
In genetics, a polygenic score (PGS) is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype. The PGS is also called the polygenic index (PGI) or genome-wide score; in the context of disease risk, it is called a polygenic risk score (PRS or PR score [1]) or genetic risk score. The score reflects an ...
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