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In histology, a lacuna is a small space, containing an osteocyte in bone, [1] or chondrocyte in cartilage. Bone
Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter.
The number of chondrocyte cells created and their maturation process can be influenced by multiple different genes and proteins. Two proteins, bone morphogenetic protein 4 (BMP-4) and fibroblast growth factor 2 (FGF2) have been seen to influence the amount of differentiation into chondrocytes. [ 4 ]
Eventually, the loss of hyaline cartilage matrix and reduction in the chondrocyte content of the hyaline cartilage matrix results in the development of joint disease such as osteoarthritis. Overexpression of hyaline-cartilage specific anabolic factors, such as FGF18, appears to restore the balance between cartilage loss and generation. [15] [16]
Lacuna (histology), a small space containing an osteocyte in bone, or chondrocyte in cartilage Muscular lacuna , a lateral compartment of the thigh Vascular lacuna , a medial compartment beneath the inguinal ligament
In embryogenesis, the skeletal system is derived from the mesoderm germ layer. Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondroblasts and begins secreting the molecules (aggrecan and collagen type II) that form the extracellular matrix.
How the Octopus Solved the Problem in the Video. When you watch the video you can see the octopus discovers the fish inside the bottle but can’t get it out.
In cases like this, the body will form a scar in the area using a special type of cartilage called fibrocartilage. [2] Fibrocartilage is a tough, dense, and fibrous material that helps fill in the torn part of the cartilage; however, it is not an ideal replacement for the smooth, glassy articular cartilage that normally covers the surface of ...