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Leiomyoma enucleated from a uterus. External surface on left; cut surface on right. Micrograph of a small, well-circumscribed colonic leiomyoma arising from the muscularis mucosae and showing fascicles of spindle cells with eosinophilic cytoplasm and elongated, cigar-shaped nuclei Immunohistochemistry for β-catenin in uterine leiomyoma, which is negative as there is only staining of cytoplasm ...
Cutaneous myxoma appears as a little, slowly expanding dermal or subcutaneous lump that typically affects adults' heads and necks. [3] Alopecic lesions have been reported, [4] [5] characterized by hair tufts overlaying the lesion or even hypertrichosis. [6] Although usually painless, some people have reported experiencing discomfort or tenderness.
Angioleiomyoma (vascular leiomyoma, angiomyoma) of the skin is thought to arise from vascular smooth muscle, and is generally acquired. [3] Angioleiomyomas appear as small (<2 cm), firm, movable, slow growing subcutaneous nodules. Pain is a common symptom. They are most commonly seen on the extremities. The cause of angioleiomyoma is unknown.
Complete removal of all tumor tissue is critical in lowering the rates of recurrences and metastases. [6] Over the long term, surgically resected LGFMS tumors have tended to recur at the site or resection in up to 75% of cases. [11] These recurrences can develop as long as 15 years (median: 3.5 years) after the initial diagnosis of the disease. [6]
In one study, metastatic disease was detected in 23% of patients and occurred at a median of 10 months (range, 2–77 months) after resection of the primary tumor. In a review of multiple studies, the risk of developing metastases for lower grade MFS (defined in the following section) was <5% and for higher grade tumors was 25–30%. [ 11 ]
Cysts that grow abnormally large, as Smith's did, can cause "pressure or pain" — and can lead to other complications, because they can bleed or rupture, exacerbating the pain.
Pseudocysts are like cysts, but lack epithelial or endothelial cells. Initial management consists of general supportive care. Symptoms and complications caused by pseudocysts require surgery. Computed tomography (CT) scans are used for initial imaging of cysts, and endoscopic ultrasounds are used in differentiating between cysts and pseudocysts.