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QTc interval prolongation (an abnormality in the electrical cycle of the heart) Photosensitivity reaction; Alopecia (hair loss) Urinary incontinence; Urinary retention, the inability to urinate. Amenorrhea the cessation of menses (a woman's menstrual cycles). This is a complication of hyperprolactinaemia. Breast enlargement (in either sex).
Most patients with drug-induced QT prolongation are asymptomatic and are diagnosed solely by EKG in association with a history of using medications known to cause QT prolongation. [7] A minority of patients are symptomatic and typically present with one or more signs of arrhythmia, such as lightheadedness, syncope, or palpitations. [7]
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. [13] It is also sometimes used off-label for treatment of chemotherapy-induced nausea and vomiting [ 14 ] and as an appetite stimulant . [ 15 ]
Asenapine and quetiapine may have interactions with medications having similar side effects, such as sedation, anticholinergic effects, weight gain, hypotension or Parkinsonism, which may cause more serious side effects. Olanzapine may be affected by cigarette smoke, while ziprasidone may cause QT prolongation if used with other drugs that have ...
AZCERT focuses on drugs and drug–drug interactions, especially those that cause QT prolongation and Torsades de Pointes (TdP) arrhythmia, and provides its research and its lists of drugs [10] free of charge to the public, healthcare providers, and researchers for personal, professional, and non-commercial purposes. To maintain the ...
There’re at least 10 specific gene mutations that are known to be linked to Long QT syndrome, which are referred to as, for example, LQT1, LQT2, and so on, all of which have some effect on one or more ion channels. Aside from congenital causes though, sometimes the QT interval can be prolonged by certain medications which affect ion channels.
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
The QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart.It is calculated as the time from the start of the Q wave to the end of the T wave, and approximates to the time taken from when the cardiac ventricles start to contract to when they finish relaxing.