Search results
Results from the WOW.Com Content Network
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. [2] [3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]
TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system. [7]
The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term ...
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A.This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.
8740 50930 Ensembl ENSG00000125735 ENSMUSG00000005824 UniProt O43557 Q9QYH9 RefSeq (mRNA) NM_003807 NM_172014 NM_001376887 NM_019418 RefSeq (protein) NP_003798 NP_742011 NP_001363816 NP_062291 Location (UCSC) Chr 19: 6.66 – 6.67 Mb Chr 17: 57.5 – 57.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a ...
Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body.