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Many pathways are involved in the abnormal proliferation and contraction of the smooth muscle cells of the pulmonary arteries in patients with pulmonary arterial hypertension. Three of these pathways are important since they have been targeted with drugs – endothelin receptor antagonists , phosphodiesterase type 5 (PDE-5) inhibitors, and ...
[1] [5] People with TIC may have symptoms associated with heart failure (e.g. shortness of breath or ankle swelling) and/or symptoms related to the tachycardia or arrhythmia (e.g. palpitations). [ 1 ] [ 2 ] Though atrial fibrillation is the most common cause of TIC, several tachycardias and arrhythmias have been associated with the disease.
Symptoms may be worse when the person is dehydrated. [10] Complications may include heart failure, an irregular heartbeat, and sudden cardiac death. [3] [4] HCM is most commonly inherited [6] in an autosomal dominant pattern. [10] It is often due to mutations in certain genes involved with making heart muscle proteins. [6]
An increase in preload results in an increased force of contraction by Starling's law of the heart; this does not require a change in contractility. An increase in afterload will increase contractility (through the Anrep effect). [4] An increase in heart rate will increase contractility (through the Bowditch effect). [4]
Mattie J.T. Stepanek (1990-2004), an American poet and peace activist, died aged 13 from dysautonomic mitochondrial myopathy, an inherited disease that causes muscle weakness and impairs heart rate, breathing, blood pressure, and digestion. Predeceased by his older siblings, he was survived by his mother (then aged 44), who was diagnosed in ...
Muscle pain from MADD is not well understood, but is partially due to high levels of lactate. Increased levels of free adenosine temporarily decrease pain, allowing over-exertion without awareness. [5] The over exertion can cause mild to severe cases of rhabdomyolysis, which is painful. [6] Adenosine mediates pain through adenosine receptors ...
This rate can be altered, however, by nerves that work to either increase heart rate (sympathetic nerves) or decrease it (parasympathetic nerves), as the body's oxygen demands change. Ultimately, muscle contraction revolves around a charged atom (ion) , calcium (Ca 2+ ) , [ 3 ] which is responsible for converting the electrical energy of the ...
The Bowditch effect, also known as the Treppe phenomenon or Treppe effect or Staircase Phenomenon, [1] [2] is an autoregulation method by which myocardial tension increases with an increase in heart rate. It was first observed by Henry Pickering Bowditch in 1871.
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