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Caspar-Klug theory has played an important part in shaping the subsequent study of viruses and other macromolecular assemblies. The original concept was based mainly on electron microscope studies, and has now been refined to take account of the atomic resolution structure of viruses , and other details of protein–protein interactions that ...
Klug's most important work is concerned with the structure of spherical viruses. Together with D. Caspar he developed a general theory of spherical shells built up of a regular array of asymmetric particles. Klug and his collaborators verified the theory by x-ray and electron microscope studies, thereby revealing new and hitherto unsuspected ...
The Caspar-Klug theory of viral capsids Topics referred to by the same term This disambiguation page lists articles associated with the title Quasi-equivalence .
Virus crystallisation is the re-arrangement of viral components into solid crystal particles. [1] The crystals are composed of thousands of inactive forms of a particular virus arranged in the shape of a prism. [2] The inactive nature of virus crystals provide advantages for immunologists to effectively analyze the structure and function behind ...
Thus, an icosahedral virus is made of 60N protein subunits. The number and arrangement of capsomeres in an icosahedral capsid can be classified using the "quasi-equivalence principle" proposed by Donald Caspar and Aaron Klug. [13] Like the Goldberg polyhedra, an icosahedral structure can be regarded as being constructed from pentamers and hexamers.
Caspar and Klug were the first to publish the most general correct construction of a geodesic polyhedron, making the name "Goldberg–Coxeter construction" an instance of Stigler's law of eponymy. [12] The discovery of Buckminsterfullerene in 1985 motivated research into other molecules with the structure of a Goldberg polyhedron.
Donald Caspar — theory of quasi-equivalence in icosahedral viruses; Alexander Chizhevsky — founder of heliobiology; Wah Chiu — cryo electron microscopy; virus structure; high-resolution cryoEM; Steven Chu — Nobel laureate who helped develop optical trapping techniques used by many biophysicists
Viral phylodynamics is the study of how epidemiological, immunological, and evolutionary processes act and potentially interact to shape viral phylogenies. [1] Since the term was coined in 2004, research on viral phylodynamics has focused on transmission dynamics in an effort to shed light on how these dynamics impact viral genetic variation.