Search results
Results from the WOW.Com Content Network
Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [ 5 ] [ 6 ] TfR1 is required for iron import from transferrin into cells by endocytosis .
Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1.
Each monomer consists of three domains: the protease, the helical, and the apical domains. The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains. [18] Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2).
Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH. TFR1 has a 30-fold higher affinity for transferrin-bound iron than TFR2 and thus is the main player in this process.
Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH. TFR1 has a 30-fold higher affinity for transferrin-bound iron than TFR2 and thus is the main player in this process.
This receptor is a protein dimer of two identical subunits, linked together by two pairs of disulfide bonds. Its molecular mass 190,000 Dalton. [1] Blood testing of the soluble transferrin receptor (sTfR) is used as a measure of functional iron status and the investigation of iron deficiency anemia.
22163 Ensembl ENSG00000186827 n/a UniProt P43489 P47741 RefSeq (mRNA) NM_003327 NM_011659 RefSeq (protein) NP_003318 NP_035789 Location (UCSC) Chr 1: 1.21 – 1.21 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR -superfamily of receptors which is not ...
8797 21933 Ensembl ENSG00000104689 ENSMUSG00000022074 UniProt O00220 Q9QZM4 RefSeq (mRNA) NM_003844 NM_020275 RefSeq (protein) NP_003835 NP_064671 Location (UCSC) Chr 8: 23.19 – 23.23 Mb Chr 14: 70 – 70.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A ...