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Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. [ 5 ]
Vitamin B 6 Drug class Pyridoxal 5'-phosphate, the metabolically active form of vitamin B 6 Class identifiers Use Vitamin B 6 deficiency ATC code A11H Biological target enzyme cofactor Clinical data Drugs.com International Drug Names External links MeSH D025101 Legal status In Wikidata Vitamin B 6 is one of the B vitamins, and is an essential nutrient for humans. The term essential nutrient ...
Pyridoxine 5′-phosphate oxidase is an enzyme, encoded by the PNPO gene, [1] [2] [3] that catalyzes several reactions in the vitamin B 6 metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B 6 metabolism, the biosynthesis of pyridoxal 5′-phosphate, the biologically active form of vitamin B 6 which acts as an essential cofactor. [4]
Pyridoxal 5′-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6, PdxST) is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase.
Pancreatitis is a common condition in cats and dogs. Pancreatitis is inflammation of the pancreas that can occur in two very different forms. Acute pancreatitis [2] is sudden, while chronic pancreatitis is characterized by recurring or persistent form of pancreatic inflammation.
Pyroluria (or malvaria from the term mauve factor) involves hypothetical excessive levels of pyrroles in the body resulting from improper hemoglobin synthesis. [13] Carl Pfeiffer believed that pyroluria is a form of schizophrenic porphyria , similar to acute intermittent porphyria where both pyrroles and porphyrins are excreted in the human ...
A mycotoxin is suspected to be involved, but none has been found in grapes or raisins ingested by affected dogs. [5] The dose-response relationship has not been determined, [2] but one study estimated 3 g/kg or greater for grapes or raisins. [6] An April 2021 letter to the editor of JAVMA hypothesized that the tartaric acid in grapes could be ...
Pyroluria can cause seizures related to vitamin B6 deficiency and is also associated with gluten/casein sensitivity. [6] Some individuals that have a seizure disorder should be cautious in the use of both evening primrose oil and vitamin B3 because these two supplements are known to lower the threshold for seizures.