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Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
The process is highly regulated by cell adhesion molecules, particularly, the addressin also known as MADCAM1. This antigen is known for its role in tissue-specific adhesion of lymphocytes to high endothelium venules. [23] Through these interactions they play a crucial role in orchestrating circulating lymphocytes.
Homophilic adhesion involves the immunoglobulin-like domains on the cell surface binding to the immunoglobulin-like domains on an opposing cell's surface while heterophilic adhesion refers to the binding of the immunoglobulin-like domains to integrins and carbohydrates instead. [21] Cell adhesion is a vital component of the body.
L1-Cell Adhesion Molecule (L1CAM) was first discovered to be important in neuron-related tissue development in the mid-1980s, and is a trans-membranal glycoprotein of approximately 200-220 kDa. On its extracellular domain, the L1CAM protein includes IgG -like and fibronectin -III (FN-III) repeats which allow for interaction with integrins and ...
Furthermore, cells can sort based upon differences in adhesion between the cells, so even two populations of cells with different levels of the same adhesion molecule can sort out. In cell culture cells that have the strongest adhesion move to the center of a mixed aggregates of cells. Moreover, cell-cell adhesion is often modulated by cell ...
In this diagram, the interface between neighboring cells or the basolateral membrane is depicted as "sheets"; the space between these sheets being the extracellular environment and the location of adhesion protein interaction. Stable cell-cell interactions are required for cell adhesion within a tissue and controlling the shape and function of ...
The term Adhesome was first used by Richard Hynes to describe the complement of cell-cell and cell-matrix adhesion receptors in an organism [1] and later expanded by Benny Geiger and co-workers to include the entire network of structural and signaling proteins involved in regulating cell-matrix adhesion. [2] [3] [4]
Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; Appearance. ... Cell adhesion molecules (5 C, 8 P) Pages in category "Cell ...