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Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. [1] The knee joint is most commonly affected. [2]
English: Microscopy with polarized light of tissue by a metatarsal joint, showing crystals whereof some (one annotated) have rhomboid shape and weak positive nirefringence, consistent with calcium pyrophosphate dihydrate crystal deposition disease (pseudogout).
A magnesium deficiency may cause chondrocalcinosis, and there is anecdotal evidence that magnesium supplementation may reduce or alleviate symptoms. [7] In some cases, arthritis from injury can cause chondrocalcinosis. [8] Other causes of chondrocalcinosis include: [4] Hypercalcaemia, especially when caused by hyperparathyroidism; Arthritis ...
Gout causes painful swelling, typically only impacting one joint. Its symptoms can come and go. Periods when gout symptoms are more severe are called gout flares or gout attacks.
Crystallopathy is a harmful state or disease associated with the formation and aggregation of crystals in tissues or cavities, [1] [2] or in other words, a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring.
Crystal arthropathy is a class of joint disorder (called arthropathy) that is characterized by accumulation of tiny crystals in one or more joints. Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate , calcium pyrophosphate dihydrate ...
[214] [215] However, whether vitamin D deficiency is a cause or a consequence of the disease remains unclear. [216] One meta-analysis found that vitamin D levels are low in people with rheumatoid arthritis and that vitamin D status correlates inversely with prevalence of rheumatoid arthritis, suggesting that vitamin D deficiency is associated ...
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