Search results
Results from the WOW.Com Content Network
It is an integral membrane protein carrier with a hydrophilic interior, which allows it to bind to glucose. As GLUT 1 is a type of carrier protein, it will undergo a conformational change to allow glucose to enter the other side of the plasma membrane. [23] GLUT 1 is commonly found in the red blood cell membranes of mammals. [24]
Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11; [ 8 ] also, the DLS motif located in the seventh transmembrane segment could be involved in the ...
A transport protein (variously referred to as a transmembrane pump, transporter, escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves the function of moving other materials within an organism. Transport proteins are vital to the growth and life of all living things.
Transcytosis is the movement of large molecules across the interior of a cell. This process occurs by engulfing the molecule as it moves across the interior of the cell and then releasing the molecule on the other side. There are two types of transcytosis are receptor-mediated transcytosis (RMT) and adsorptive-mediated transcytosis (AMT).
GLUT2 has high capacity for glucose but low affinity (high K M, ca. 15–20 mM) and thus functions as part of the "glucose sensor" in the pancreatic β-cells of rodents, though in human β-cells the role of GLUT2 seems to be a minor one. [8] It is a very efficient carrier for glucose.
Mechanisms are based on energy-induced conformational changes of the protein structure or on the Q cycle. During evolution, proton pumps have arisen independently on multiple occasions. Thus, not only throughout nature, but also within single cells, different proton pumps that are evolutionarily unrelated can be found.
The glucose transporter (GLUTs) is a type of uniporter responsible for the facilitated diffusion of glucose molecules across cell membranes. [9] Glucose is a vital energy source for most living cells, however, due to its large size, it cannot freely move through the cell membrane. [16]
Where the hydrolysis of the energy provider is indirect as is the case in secondary active transport, use is made of the energy stored in an electrochemical gradient. For example, in co-transport use is made of the gradients of certain solutes to transport a target compound against its gradient, causing the dissipation of the solute gradient ...