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Amitriptyline. Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [12] Due to the frequency and prominence of side effects, amitriptyline is generally ...
Tricyclic antidepressants ( TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [1] They are named after their chemical structure, which contains three rings of atoms. Tetracyclic antidepressants (TeCAs), which contain four rings of atoms ...
Nortriptyline is a tricyclic compound, specifically a dibenzocycloheptadiene, and possesses three rings fused together with a side chain attached in its chemical structure. [41] Other dibenzocycloheptadiene TCAs include amitriptyline ( N -methylnortriptyline), protriptyline, and butriptyline. [41] [42] Nortriptyline is a secondary amine TCA ...
Similar to other TCAs, amitriptyline is more likely to cause certain side effects than newer medications. A study by JAMA Psychiatry found that amitriptyline is one of the depression medications ...
Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature, blurred vision, dilated pupils, sleepiness, confusion, seizures, rapid heart rate, and cardiac arrest. [ 1]
Due to its side effects, amitriptyline isn’t commonly used as a first-line treatment for depression. Viorel Kurnosov/istockphoto Another well-known TCA is doxepin, sold under the name Silenor.
Common (>1% incidence) adverse effects include. Sedation; Hypertension; Neurological impairments (such as extrapyramidal side effects which include dystonia, akathisia, parkinsonism, muscle rigidity, etc.)
Tianeptine shows efficacy against serious depressive episodes ( major depression ), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. [ 18] It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. [ 10]
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