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Most research indicates that an increase of 0.75 ng/mL a year is an early indicator of prostate cancer if a man has a total PSA result between 4.0 and 10.0 ng/mL. An increase of 2.0 ng/mL over a year predicts a higher likelihood of death due to aggressive prostate cancer.
Generally speaking, though, PSA levels for men who are: Age 60 or older: should be at or below 4.0 mg/mL; Age 59 or younger: should be at or below 2.5 mg/mL; The average PSA for men in the younger group is <1.0 mg/mL. Why are my PSA levels elevated? Your PSA levels could be elevated for many reasons.
Decoding a PSA Test Doctors will consider your age and the size of your prostate when determining what your PSA score means. In general: For men in their 40s and 50s: A PSA score greater than 2.5 ng/ml is considered abnormal. The median PSA for this age range is 0.6 to 0.7 ng/ml.
The PSA test can detect high levels of PSA that may indicate the presence of prostate cancer. However, many other conditions, such as an enlarged or inflamed prostate, also can increase PSA levels. Therefore, determining what a high PSA score means can be complicated.
Eleven per cent of men (n=155) had a PSA level of ≥ 6.5 ng/mL (the suggested cut-off for further investigation for men aged 70 or over, from an American study), increasing from 7.5% of men aged 70–74 years to 31.4% of men aged ≥ 90 years.
The task force recommends that men ages 55 to 69 make a shared decision with their doctors regarding routine prostate cancer screening, which usually means periodic blood tests for prostate-specific antigen (PSA). The task force advises men to stop screening once they reach age 70.
Doctors usually consider PSA levels below 4 ng/mL typical if you’re between 40–70 years old. But what’s typical may vary by age and other individual factors.