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Genes encoding human Ly6 family members are located in clusters on chromosomes 6, 8, 11 and 19. In the murine genome family members are located on chromosomes 17, 15, 9 and 7, respectively. [ 4 ] [ 3 ] [ 1 ] Genes encoding Ly6 proteins with one LU domain consist of 3 exons and 2 introns .
79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
A duplication of the gene has been detected in a case study of two individuals with severe intellectual disability, suggesting its role in proper brain development and cognitive function. [10] Additionally, the protein demonstrates high expression in several other normal organs including the testis , lungs , stomach , and prostate .
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [5] [6] [7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [8]
The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.
Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene. [5] [6] This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. [7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors. [8]
72434 Ensembl ENSG00000124466 ENSMUSG00000057454 UniProt O95274 Q91YK8 RefSeq (mRNA) NM_014400 NM_133743 RefSeq (protein) NP_055215 NP_598504 Location (UCSC) Chr 19: 43.46 – 43.47 Mb Chr 7: 24.34 – 24.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ly6/PLAUR domain-containing protein 3 is a protein that in humans is encoded by the LYPD3 gene. References ^ a b c GRCh38: Ensembl ...
CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. [5] It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. [6] CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor.