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For example, a PI of 25,000 platelets/μL, a BSA of 1.8m 2 and a PD of 4x10 11 gives a CCI of 11,250 platelets*m 2 /10 11 μL At 1 hour post-transfusion a CCI greater than 7500 indicates a sufficient post-transfusion increment, whereas a CCI less than 7500 is considered diagnostic of platelet refractoriness. [ 10 ]
Unlike other blood products demand for platelet transfusions appears to be increasing in several countries around the world. [27] An ageing population, an increase in the number of people with blood cancer, and changes to the management of these cancers are likely the major reasons for the rise in demand for platelets. [27]
Platelets collected by using apheresis at an American Red Cross donation center. Not all platelet transfusions use platelets collected by automated apheresis. The platelets can also be separated from donations of whole blood collected in a traditional blood donation, but there are several advantages to separating the platelets at the time of collection.
Platelets are either isolated from collected units of whole blood and pooled to make a therapeutic dose, or collected by platelet apheresis: blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor in a closed loop. The industry standard is for platelets to be tested for ...
The automated red blood cell collection procedure for donating erythrocytes is referred to as 'Double Reds' or 'Double Red Cell Apheresis.' [9] Plateletpheresis (thrombapheresis, thrombocytapheresis) – blood platelets. Plateletpheresis is the collection of platelets by apheresis while returning the RBCs, WBCs, and component plasma.
Plasma is the "yellowish" liquid part of blood, which acts as a buffer and contains proteins and other important substances needed for the body's overall health. Platelets are involved in blood clotting, preventing the body from bleeding. Before these components were known, doctors believed that blood was homogeneous.
Universal leukoreduction is currently not practiced in all countries. [citation needed]As of 2008, most developed nations have adopted universal leukoreduction of transfusions (defined as the routine application of this blood-processing step to all units of whole blood, red blood cells, and platelets prior to storage) with the notable exception of the United States. [8]
Prevention includes gamma irradiation of the lymphocyte-containing blood components such as red blood cells, platelets and granulocytes. Irradiated blood components should be issued in the following situations: [7] Intrauterine transfusions; Prematurity, low birthweight, or erythroblastosis fetalis in newborns; Congenital immunodeficiencies
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