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Its main offices were located in Gaithersburg, MD, Cambridge, UK, and Mountain View, CA. [ 4 ] It produced Synagis , a drug for the prevention of respiratory infections in infants, which accounted for US$ 1.06 billion of its US$ 1.2 billion in revenue for 2005, and FluMist , a nasal spray influenza vaccine introduced in 2004.
Lymph returns proteins and excess interstitial fluid to the bloodstream. Lymph also transports fats from the digestive system (beginning in the lacteals) to the blood via chylomicrons. Bacteria may enter the lymph channels and be transported to lymph nodes, where the bacteria are destroyed. Metastatic cancer cells can also be transported via lymph.
Because Ficoll-Paque layering is a very slow process, devices that aid in the most time-consuming step, the overlay, have been developed. One such product is SepMate-50, [2] a specialized tube containing a porous insert that forms a physical barrier between the Ficoll-Paque and blood sample. This allows the blood sample to be rapidly pipetted ...
Vaccinogen Inc. is a US biotechnology company based in Baltimore. It is currently developing a potential cancer immunotherapy called OncoVAX, where a patient's own tumor cells are used as the vaccine, adjuvanted by BCG.
Ipilimumab, sold under the brand name Yervoy, is a monoclonal antibody medication that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system.
Lymphovascular invasion, especially in carcinomas, usually precedes spread to the lymph nodes that drain the tissue in which the tumour arose. Conversely, cancers with lymph node spread (known as a lymph node metastases), usually have lymphovascular invasion. Lymph node metastases usually precede secondary tumours, i.e. distant metastases.
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Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles including cancer cells, but have no detoxification function. In the lymphatic system, a lymph node is a secondary lymphoid organ. A lymph node is enclosed in a fibrous capsule and is made up of an outer cortex and an inner medulla.