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By tradition, the term idiopathic thrombocytopenic purpura is used when the cause is idiopathic, or unknown. However, most cases are now considered to be immune-mediated. [citation needed] Another form is thrombotic thrombocytopenic purpura. [citation needed]
Other causes of thrombocytopenia which may occur in pregnancy, such as drug induced thrombocytopenia, hereditary thrombocytopenia and pseudothrombocytopenia should also be ruled out. [63] ITP can be difficult to distinguish from gestational thrombocytopenia (which is by far the most common cause of thrombocytopenia in pregnancy). Unlike ITP ...
Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count , low red blood cells due to their breakdown , and often kidney , heart , and brain dysfunction. [ 1 ]
Immunosuppressive drugs are the most common treatment with corticosteroids being commonly used. [16] Vincristine and human intravenous immunogoblin have been shown to increase platelet count and improve recovery; however, none of these treatments have been shown to produce better long term survival than corticoseroid treatment.
Immune thrombocytopenic purpura is a condition in which platelets are destroyed by an autoimmune process. Platelets are a component of blood that contribute to the formation of blood clots in the body to prevent bleeding. The syndrome was first described in 1951 by R. S. Evans and colleagues. [1]
Drug-induced thrombocytopenic purpura is a skin condition result from a low platelet count due to drug-induced anti-platelet antibodies caused by drugs such as heparin, sulfonamides, digoxin, quinine, and quinidine. [1]: 821
There are numerous causes of palpable purpura, such as autoimmune diseases, drug reactions, vaccinations, and infections.The most common infectious causes are N. gonorrhoeae, S. aureus, and N. meningitides, however palpable purpura has also been caused by Mycoplasma spp., Rickettsiae, Mycobacterium, and very rarely by Treponema pallidum, Brucella spp., Yersinia, Campylobacter, and Bartonella.
[citation needed] In many cases where acute thrombosis and thrombocytopenia have been found together after COVID‑19 vaccination, an antibody against platelet factor 4 has been identified. [1] This phenomenon is mostly encountered in some people who have been administered heparin , but none of the reported cases had received heparin. [ 1 ]
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