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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Likewise, Viagra shouldn’t be combined with antiretroviral drugs used to treat HIV/AIDS, as it can cause an increased concentration of sildenafil in the body. Breastfeeding women shouldn’t ...
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
For most men, sildenafil is a safe and effective treatment for ED when used as prescribed. However, like all drugs, it comes with its own set of potential side effects and interactions.
Life-threatening problems can result when drug interactions between your daily medications cause side effects, and nowhere might that be more clear than with Viagra and high blood pressure.
Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra. It was approved by the Food and Drug Administration (FDA) in 1998 as the first oral medicine for erectile dysfunction. Later, in the year 2005, it was approved for the treatment of pulmonary arterial hypertension. [2] Vardenafil and tadalafil were discovered in 1990.
Viagra is an effective ED treatment that can improve performance, make arousals firmer, and improve your intimate life. Since those benefits are attractive whether you have ED or not, some men ...
Sildenafil 100 milligram tablets. Libido refers to a person's overall sexual desire and drive. Since low testosterone levels are associated with low sexual desire, testosterone replacement therapy can be prescribed for increasing testosterone in the body, increasing libido and restoring hormonal balance. [66]