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An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
Randy Jirtle (born November 9, 1947) is an American biologist noted for his research in epigenetics, the branch of biology that deals with inherited information that does not reside in the nucleotide sequence of DNA. [1]
Punnett square for the agouti gene in mice, demonstrating a recessive lethal allele. [2] Lethal alleles were first discovered by Lucien Cuénot in 1905 while studying the inheritance of coat colour in mice. The agouti gene in mice is largely responsible for determining coat colour. The wild-type allele produces a blend of yellow and black ...
The gene associated with the Cream coat colors is also a solute carrier, and orthologous genes in humans, mice, and other species are also linked to coat color phenotypes. [36] The single nucleotide polymorphism responsible for the champagne phenotype is a missense mutation in exon 2, in which a C is replaced with a G, such that a threonine is ...
A cat hair showing agouti coloration A domestic rabbit with agouti coloration. Agouti is a type of fur coloration in which each hair displays two or more bands of pigmentation. [1] [2] The overall appearance of agouti fur is usually gray or dull brown, [3] although dull yellow is also possible.
11604 Ensembl ENSG00000159723 ENSMUSG00000005705 UniProt O00253 P56473 RefSeq (mRNA) NM_001138 NM_001271806 NM_007427 RefSeq (protein) NP_001129 NP_001258735 NP_031453 Location (UCSC) Chr 16: 67.48 – 67.48 Mb Chr 8: 106.29 – 106.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the ...
The agouti (/ ə ˈ ɡ uː t iː / ⓘ, ə-GOO-tee) or common agouti is many of several rodent species of the genus Dasyprocta. They are native to Central America , northern and central South America , and the southern Lesser Antilles .