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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics .
The Compendious Book on Calculation by Completion and Balancing. ... Download as PDF; Printable version; In other projects ... This page was last edited on 2 November ...
The Compendium of Pharmaceuticals and Specialties: The Canadian Drug Reference for Health Professionals, more commonly known by its abbreviation CPS, [1] is a reference book that contains drug monographs and numerous features which help healthcare professionals prescribe and use drugs safely and appropriately.
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Martindale: The Complete Drug Reference is a reference book published by Pharmaceutical Press listing some 6,000 drugs and medicines used throughout the world, including details of over 125,000 proprietary preparations. It also includes almost 700 disease treatment reviews.
Oral drugs are normally taken as tablets or capsules. The drug (active substance) itself needs to be soluble in aqueous solution at a controlled rate.Such factors as particle size and crystal form can significantly affect dissolution.
English-speaking countries also used a system of units of fluid measure, or in modern terminology volume units, based on the apothecaries' system. Originally, the terms and symbols used to describe the volume measurements of liquids were the same as or similar to those used to describe weight measurements of solids [33] (for example, the pound by weight and the fluid pint were both referred to ...