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Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with Trypanosoma cruzi, commonly referred to as Chagas disease. [14] Like other nitroimidazoles, benznidazole's main mechanism of action is to generate radical species which can damage the parasite's DNA or cellular machinery . [ 17 ]
In Chagas disease it is a second-line option to benznidazole. [5] It is given by mouth. [2] Common side effects include abdominal pain, headache, nausea, and weight loss. [2] There are concerns from animal studies that it may increase the risk of cancer but these concerns have not been found in human trials. [5]
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
Two widely touted Alzheimer’s drugs have been shown to enable patients to remain in their homes for longer periods of time. Those medications, however, are not without their risks and side effects.
For example, a failure rate of 20% means that 20 of 100 women become pregnant during the first year of use. Note that the rate may go above 100% if all women, on average, become pregnant within less than a year. In the degenerated case of all women becoming pregnant instantly, the rate would be infinite.
The probability of success (POS) is a statistics concept commonly used in the pharmaceutical industry including by health authorities to support decision making. The probability of success is a concept closely related to conditional power and predictive power .
Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.
Three of the four highest-grossing films, including Avatar at the top, were written and directed by James Cameron.. With a worldwide box-office gross of over $2.9 billion, Avatar is proclaimed to be the "highest-grossing" film, but such claims usually refer to theatrical revenues only and do not take into account home video and television income, which can form a significant portion of a film ...