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Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is a fatal neurodegenerative disease. [ 4 ] [ 1 ] Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. [ 4 ]
Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]).
The Creutzfeldt-Jakob Disease Surveillance System (CJDSS) is a unit of the Public Health Agency of Canada. It studies the various variants of Creutzfeldt-Jakob Disease , and at least as of 2017, assisted "with DNA sequencing , autopsy and case confirmation". [ 1 ]
Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. [1] Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. [1] [2] [3] He was born in Harburg an der Elbe and died in Munich.
The structures of solid magnesium citrates have been characterized by X-ray crystallography.In the 1:1 salt, only one carboxylate of citrate is deprotonated. It has the formula Mg(H 2 C 6 H 5 O 7) 2 The other form of magnesium citrate has the formula Mg(HC 6 H 5 O 7)(H 2 O) 2, consisting of the citrate dianion (both carboxylic acids are deprotonated). [1]
[1] [2] [3] In combination with 30 μg EE, a single 2 mg oral dose of CMA produced maximal serum levels of 1.6 ng/mL after about 1 to 2 hours and chronic administration produced steady-state levels of 2.0 ng/mL. [1] [5] [2] Steady-state concentrations of CMA are achieved after 7 to 15 days. [2] [5] The distribution half-life of CMA is about 2.5 ...
The 2022 deaths of two hunters who ate venison infected with chronic wasting disease (CWD) has raised concerns the illness could pass to humans.
Jonathan Simms (1 June 1984 – 5 March 2011) was a man from Belfast, Northern Ireland, who contracted variant Creutzfeldt–Jakob disease (vCJD) in his late teenage years. He was given a post-diagnosis life expectancy of one year, similar to that of other young people who were diagnosed in the same age bracket.