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The concept of replacing hydrogen with deuterium is an example of bioisosterism, whereby similar biological effects to a known drug are produced in an analog designed to confer superior properties. [5] The first patent in the US granted for deuterated molecules was in the 1970s. Since then patents on deuterated drugs have become more common. [6]
The deuteration pattern of a molecule that has undergone H/D exchange can be maintained in aprotic environments. However, some methods of deuteration analysis for molecules such as proteins, are performed in aqueous solution, which means that exchange will continue at a slow rate even after the reaction is quenched.
There is an even higher-yield 2 H– 3 He fusion reaction, though the breakeven point of 2 H– 3 He is higher than that of most other fusion reactions; together with the scarcity of 3 He, this makes it implausible as a practical power source, at least until DT and deuterium–deuterium (DD) fusion have been performed on a commercial scale ...
Deuterated acetone is prepared by the reaction of acetone with heavy water, 2 H 2 O or D 2 O, in the presence of a base. In this case, the base used is deuterated lithium hydroxide : [ 1 ] In order to fully deuterate the acetone, the process is repeated several times, distilling off the acetone from the heavy water, and re-running the reaction ...
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Plant biochemistry encompasses the chemical reactions that occur within plants. In principle, knowledge at a molecular level informs technologies for providing food. Particular focus is on the biochemical differences between plants and other organisms as well as the differences within the plant kingdom, such as dicotyledons vs monocotyledons, gymnosperms vs angiosperms, C2- vs C4-fixer
For example, deuterated benzene could be used in the synthesis of deuterated benzoic acid, if desired: Many simple monosubstituted aromatic compounds bearing the deuterated phenyl (C 6 D 5 ) group may be purchased commercially, such as aniline , acetophenone , nitrobenzene , bromobenzene , and more.
The azide alkyne Huisgen cycloaddition [5] is a mild and selective reaction that gives 1,2,3-triazoles as products. The reaction has been widely used in bioorthogonal chemistry and in organic synthesis. Triazoles are relatively stable functional groups and triazole linkages can be used in a variety of applications, e.g. replacing the phosphate ...